The grenade launcher was designed by Viktor Rebrikov and put into service with the Russian Navy in small numbers in 1990. As of 2015, the DP-64 is in mass production, as the Russian Defense Ministry received an order from Abu Dhabi for a large amount of DP-64s.
The weapon is designed to protect dockyards with its specialized grenades. It is breech-loaded and loads from the side of the weapon with the use of a side-breaking mechanism. Barrels for the weapon are selected using a lever situated above the pistol grip. The weapon has rubber padding at the rear to help reduce felt recoil for the user. A front grip is added for support when firing indirectly.
The DP-64 uses various types of 45mm grenades, which are the FG-45, a fragmentation grenade with a 14 meter (45.9 feet) blast radius and a 40 meter (131.2 feet) radius underwater, the SG-45, a flare grenade that emits a red light for roughly 50 seconds, and the UG-45 grenade, which is a high-explosive/concussion grenade.